Wearable Anaphylaxis Detection for Improved Safety and Phenotyping
Funded by Food Allergy Fund
Dr. Mary Grace Baker and Dr. Hugh Sampson as Principal Investigators
Anaphylaxis is a rapid, life-threatening allergic reaction that can be triggered during oral food challenges (OFCs)—the gold standard for diagnosing food allergies. However, current diagnostic methods rely heavily on subjective observation and patient reporting, which are particularly limited in infants, toddlers, and anxious children. Our team's goal is to improve the safety and accuracy of OFCs by identifying early physiological signals that precede visible allergic reactions. Using biometric data collected from wearable wristband devices (an Analog Devices sensor band or Samsung Galaxy Watch), paired with proprietary software and algorithms developed by Anjo.ai, we aim to detect subtle changes in physiology that indicate early onset of anaphylaxis. By analyzing this data throughout the course of OFCs, we hope to develop tools that support earlier intervention, reduce reaction severity, and ultimately enhance clinical outcomes for children undergoing allergy testing.